250 cc Championship
| YEAR | PILOTS | MAKERS | ||||
| WINNER | SECOND | THIRD | WINNER | SECOND | THIRD | |
| 1949 | Bruno Ruffo (I) (Guzzi) | Dario Ambrosini (I) (Benelli) | Ronald Mead (GB) (Norton) | Moto Guzzi | Benelli | Norton |
| 1950 | Dario Ambrosini (I) (Benelli) | Maurice Cann (GB) (Guzzi) | Bob Anderson (GB) (Guzzi) | Benelli | Guzzi | Excelsior |
| 1951 | Bruno Ruffo (I) (Guzzi) | Russel Wood (ZA) (Guzzi) | Dario Ambrosini (I) (Benelli) | Guzzi | Benelli | Velocette |
| 1952 | Enrico Lorenzetti (I) (Guzzi) | Bob Anderson (GB) (Guzzi) | Leslie Graham (GB) (Velocette) | Guzzi | Velocette | DKW |
| 1953 | Werner Haas (D) (NSU) | Keith Armstrong (GB) (NSU) | Bob Anderson (GB) (Guzzi) | NSU | Guzzi | DKW |
| 1954 | Werner Haas (D) (NSU) | Rupert Hollaus (A) (NSU) | Hans Muller (CH) (NSU) | NSU | Guzzi | Adler |
| 1955 | Herman Peter Muller (D)(NSU) | Bill Lomas (GB) (MV Agusta) | Cecil Sandford (GB) (Guzzi) | MV Agusta | NSU | Rd Special |
| 1956 | Carlo Ubbiali (I) (MV Agusta) | Luigi Taveri (CH) (MV Agusta) | Enrico Lorenzetti (I) (Guzzi) | MV Agusta | Guzzi | NSU |
| 1957 | Cecil Sandford (GB) (FB-Mondial) | Tarquino Provini (I) (FB-Mondial) | Sammy Miller (IRL) (FB-Mondial) | FB-Mondial | MV Agusta | NSU |
| 1958 | Tarquino Provini (I) (MV Agusta) | Horst Fugner (D) (MZ) | Carlo Ubbiali (I) (MV Agusta) | MV Agusta | MZ | NSU |
| 1959 | Carlo Ubbiali (I) (MV Agusta) | Gary Hocking (RHO) (MZ) | Tarquino Provini (I) (MV Agusta) | MV Agusta | MZ | Morini |
| 1960 | Carlo Ubbiali (I) (MV Agusta) | Gary Hocking (RHO) (MV Agusta) | Luigi Taveri (CH) (MV Agusta) | MV Agusta | Honda | Mondial |
| 1961 | Mike Hailwood (GB) (Honda) | Tom Phillis (AUS) (Honda) | Jim Redman (RHO) (Honda) | Honda | Morini | Benelli |
| 1962 | Jim Redman (RHO) (Honda) | Bob McIntyre (GB) (Honda) | Arthur Wheeler (GB) (Guzzi) | Honda | Guzzi | Morini |
| 1963 | Jim Redman (RHO) (Honda) | Tarquino Provini (I) (Morini) | Fumio Ito (J) (Yamaha) | Honda | Morini | Yamaha |
| 1964 | Phil Read (GB) (Honda) | Jim Redman (RHO) (Honda) | Alan Shepard (GB) (MZ) | Yamaha | Honda | MZ |
| 1965 | Phil Read (GB) (Yamaha) | Mike Duff (CDN) (Yamaha) | Jim Redman (RHO) (Honda) | Yamaha | Honda | MZ |
| 1966 | Mike Hailwood (GB) (Honda) | Phil Read (GB) (Yamaha) | Jim Redman (RHO) (Honda) | Honda | Yamaha | MZ |
| 1967 | Mike Hailwood (GB) (Honda) | Phil Read (GB) (Yamaha) | Bill Ivy (GB) (Yamaha) | Honda | Yamaha | MZ |
| 1968 | Phil Read (GB) (Yamaha) | Bill Ivy (GB) (Yamaha) | Heinz Rosner (D) (MZ) | Yamaha | MZ | Bultaco |
| 1969 | Kelvin Carruthers (AUS)(Benelli) | Kent Anderson (S) (Yamaha) | Santiago Herrero (E) (Ossa) | Benelli | Yamaha | Ossa |
| 1970 | Rodney Gould (GB) (Yamaha) | Kelvin Carruthers (AUS)(Yamaha) | Kent Anderson (S) (Yamaha) | Yamaha | Ossa | MZ |
| 1971 | Phil Read (GB) (Yamaha) | Rodney Gould (GB) (Yamaha) | Jarno Saarinen (SF) (Yamaha) | Yamaha | MZ | Kawasaki |
| 1972 | Jarno Saarinen (SF) (Yamaha) | Renzo Pasolini (Aermacchi) | Rodney Gould (GB) (Yamaha) | Yamaha | Aermacchi | Maico |
| 1973 | Dieter Braun (D) (Yamaha) | Tevo Lansivuori (SF) (Yamaha) | John Dodds (AUS) (Yamaha) | Yamaha | Harley Davidson | MZ |
| 1974 | Walter Villa (I) (Harley-Davidson) | Dieter Braun (D) (Yamaha) | Patrick Pons (F) (Yamaha) | Yamaha | Harley Davidson | Dugdale Maxton Yamaha |
| 1975 | Walter Villa (I) (Harley-Davidson) | Michel Rugerie (F) (Harley-Davidson) | Dieter Braun (D) (Yamaha) | Harley-Davidson | Yamaha | Derbi |
| 1976 | Walter Villa (I) (Harley-Davidson) | Takazumi Katayami (J) (Yamaha) | Gianfranco Bonera (I) (Harley-Davidson) | Harley-Davidson | Yamaha | Morbidelli |
| 1977 | Mario Lega (I) (Morbidelli) | Franco Uncini (I) (Harley-Davidson) | Walter Villa (I) (Harley-Davidson) | Yamaha | Harley-Davidson | Morbidelli |
| 1978 | Kork Ballington (ZA) (Kawasaki) | Greg Hansford (AUS) (Kawasaki) | Patrick Fernandez (F) (Yamaha) | Kawasaki | Yamaha | Morbidelli |
| 1979 | Kork Ballington (ZA) (Kawasaki) | Greg Hansford (AUS) (Kawasaki) | Graziano Rossi (I) (Morbidelli) | Kawasaki | Yamaha | Morbidelli |
| 1980 | Anton Mang (D) (Kawasaki) | Kork Ballington (ZA) (Kawasaki) | Jean Francois Baldé (F) (Kawasaki) | Kawasaki | Yamaha | Morbidelli |
| 1981 | Anton Mang (D) (Kawasaki) | Jean Francois Baldé (F) (Kawasaki) | Roland Freymond (CH) (Ad Majora) | Kawasaki | Yamaha | Ad Majora |
| 1982 | Jean-Louis Tournadre (F) (Yamaha) | Anton Mang (D) (Kawasaki) | Roland Freymond (CH) (MBA) | Yamaha | Kawasaki | MBA |
| 1983 | Carlos Lavado (YV) (Yamaha) | Christian Sarron (F) (Yamaha) | Didier De Radigues (B) (Chevallier) | Yamaha | Chevallier | Kawasaki |
| 1984 | Christian Sarron (F) (Yamaha) | Manfred Herweh (D) (Real) | Carlos Lavado (YV) (Yamaha) | Yamaha | Real | JJ Cobas |
| 1985 | Freddie Spencer (USA) (Honda) | Anton Mang (D) (Honda) | Carlos Lavado (YV) (Yamaha) | Honda | Yamaha | Aprilia |
| 1986 | Carlos Lavado (YV) (Yamaha) | Sito Pons (E) (Honda) | Dominique Sarron (F) (Honda) | Honda | Yamaha | Armstrong |
| 1987 | Anton Mang (D) (Honda) | Reinhold Roth (D) (Honda) | Sito Pons (E) (Honda) | Honda | Yamaha | Aprilia |
| 1988 | Sito Pons (E) (Honda) | Juan Garriga (E) (Yamaha) | Jacques Cornu (CH) (Honda) | Honda | Yamaha | Aprilia |
| 1989 | Sito Pons (E) (Honda) | Reinhold Roth (D) (Honda) | Jacques Cornu (CH) (Honda) | Honda | Yamaha | Aprilia |
| 1990 | Jonh Kocinski (USA) (Yamaha) | C. Cardus (Honda) | Luca Cadalora (I) (Yamaha) | Yamaha | Honda | Aprilia |
| 1991 | Luca Cadalora (I) (Honda) | H. Bradl (Honda) | C. Cardus (Honda) | Honda | Aprilia | Yamaha |
| 1992 | Luca Cadalora (I) (Honda) | Loris Reggiani (I) (Aprilia) | Pierfrancesco Chili (I) (Aprilia) | Honda | Aprilia | Yamaha |
| 1993 | Tetsuya Harada (J) (Yamaha) | Loris Capirossi (I) (Honda) | Loris Reggiani (I) (Aprilia) | Honda | Yamaha | Aprilia |
| 1994 | Massimiliano Biaggi (I) (Aprilia) | Tadayuka Okada (J) (Honda) | Loris Capirossi (I) (Honda) | Honda | Aprilia | Yamaha |
| 1995 | Massimiliano Biaggi (I) (Aprilia) | Tetsuya Harada (J) (Yamaha) | Ralf Waldmann (D) (Honda) | Aprilia | Honda | Yamaha |
| 1996 | Massimiliano Biaggi (I) (Aprilia) | Ralf Waldmann (D) (Honda) | Olivier Jacque (F) (Honda) | Honda | Aprilia | Yamaha |
| 1997 | Massimiliano Biaggi (I) (Honda) | Ralf Waldmann (D) (Honda) | Tetsuya Harada (J) (Aprilia) | Honda | Aprilia | Yamaha |
| 1998 | Loris Capirossi (I) (Aprilia) | Valentino Rossi (I) (Aprilia) | Tetsuya Harada (J) (Aprilia) | Aprilia | Honda | Yamaha |
| 1999 | Valentino Rossi (I) (Aprilia) | Tohru Ukawa (J) (Honda) | Loris Capirossi (I) (Honda) | Aprilia | Honda | Yamaha |
| 2000 | Olivier Jacque (F) (Yamaha) | Shinya Nakano (J) (Yamaha) | Daijiro Kato (J) (Honda) | Yamaha | Honda | Aprilia |
| 2001 | Daijiro Kato (J) (Honda) | Tetsuya Harada (J) (Aprilia) | Marco Melandri (I) (Aprilia) | Honda | Aprilia | Yamaha |
| 2002 | Marco Melandri (I) (Aprilia) | Alfonso Nieto (E) (Aprilia) | Roberto Rolfo (I) (Honda) | Aprilia | Honda | Yamaha |
| 2003 | Manuel Poggiali (RSM) (Aprilia) | Roberto Rolfo (I) (Honda) | Antonio Elias (E) (Aprilia) | Aprilia | Honda | Yamaha |
| 2004 | Daniel Pedrosa (E) (Honda) | Sebastian Porto (RA) (Aprilia) | Randy de Puniet (F) (Aprilia) | Honda | Aprilia | Yamaha |
| 2005 | Daniel Pedrosa (E) (Honda) | Casey Stoner (AUS) (Aprilia) | Andrea Dovizioso (I) (Honda) | Honda | Aprilia | KTM |
| 2006 | Jorge Lorenzo (E) (Aprilia) | Andrea Dovizioso (I) (Honda) | Alex De Angelis (RSM) (Aprilia) | Aprilia | Honda | KTM |
| 2007 | Jorge Lorenzo (E) (Aprilia) | Andrea Dovizioso (I) (Honda) | Alex De Angelis (RSM) (Aprilia) | Aprilia | Honda | KTM |
| 2008 | Marco Simoncelli (I) (Gilera) | Alvaro Bautista (E) (Aprilia) | Mikka Kallio (SF) (KTM) | Aprilia | KTM | Honda |
| 2009 | Hiroshi Aoyama (J)(Honda) | Hector Barbera (E) (Aprilia) | Marco Simoncelli (I) (Gilera) | Aprilia | Honda | Gilera |